Endorys Matrix
A proposed conformal sensing interface, with contact quality, acoustic coupling and sensor geometry as explicit design requirements.
Concept architecture RESEARCH LIBRARY · BENGALURU, INDIA
The research behind
the architecture.
Endorys investigates the measurement conditions needed to characterize tissue response with ultrasound. This library brings together the proposed architecture, application questions and validation priorities.
DEVELOPMENT STATUS
Pre-prototype research · Selective openness.
Physical and clinical validation remain outstanding.
THE ENDORYS CONCEPTINTERFACE → INSIGHT
01 / SENSING INTERFACE
Characterize the interface.
Proposed conformal sensing with contact, coupling and sensor position documented.
02 / CONTROLLED ACQUISITION
Control the acquisition.
Acoustic response capture with traceable acquisition conditions.
03 / CALIBRATED ANALYSIS
Assess the response.
Investigate response estimates with explicit calibration requirements and uncertainty.
Concept illustration—not a prototype or measured output.
Research architectureValidation planned
01 / RESEARCH ARCHITECTUREA connected architecture.
A connected architecture.
From sensing to analysis.
The measurement question: how can tissue response be characterized repeatably when contact, sensor geometry and acquisition conditions vary?
The proposed architecture combines a conformal sensing interface, controlled acoustic acquisition and external analysis. Sensor geometry, contact conditions and uncertainty are treated as part of the measurement record.
The Acoustic Reference Test (E001) is the first planned bench study, aimed at establishing a reproducible acoustic baseline. An integrated sensing module would then be evaluated against that reference. Clinical usefulness requires separate investigation.
Read the architecture ↗Controlled acoustics
Source selection, synchronized response capture and traceable acquisition metadata, to be evaluated against a conventional acoustic reference.
Bench validation plannedEndorys Insight
Signal analysis and reconstruction research, with explicit calibration requirements and uncertainty. Synthetic examples support inspection of the analysis workflow.
Research software examplesExplore the full platform concept
02 / APPLICATION DISCOVERYClinical questions.
Clinical questions.
Defined evidence requirements.
Application candidates inform the research programme. Each requires a defined intended use and separate validation; no clinical indication is established.
Breast tissue research
Investigate the measurement requirements for repeatable acoustic characterization of tissue response. Breast assessment is the original motivation for Endorys.
- Research question
- Can a consistent sample response be distinguished from changes in acquisition conditions and sensor geometry?
- Evidence needed
- A reproducible phantom baseline, followed by a defined intended use and an appropriately designed study with expert oversight and relevant approvals.
No screening, cancer detection or diagnostic performance is claimed.
The initial experiment uses a non-biological phantom. Human application illustrations describe future research concepts and do not establish clinical performance.
THE RESEARCH LIBRARYTwelve workstreams.
Twelve workstreams.
A shared validation framework.
The workstreams organize architecture, applications and validation. They define research scope, not available products or established clinical indications.
Explore all 12 research workstreams
Showing all 12 research workstreams.
03 / DEVELOPMENT ROADMAPDevelopment milestones.
Development milestones.
Evidence at each stage.
Each stage requires defined evidence before the programme advances. These milestones are conditional, not launch commitments or completed results.
NEXT TECHNICAL MILESTONE
Read the E001 protocol ↗Acoustic Reference Test
The Acoustic Reference Test (E001) is planned around a conventional water-path setup and a non-biological sample. It will assess timing, placement and temperature effects on repeatability. Physical results have not yet been established.
- 01CURRENT STAGEGate: reviewable experiment
Review the architecture and experimental design
Architecture documentation, experimental plans and synthetic analysis examples are available for independent review.
- 02NEXT TECHNICAL MILESTONEGate: measured repeatability
Establish the acoustic reference
Execute the reviewed protocol and document repeatability, uncertainty, acquisition conditions and unsuccessful runs.
- 03CONDITIONALGate: justified engineering benefit
Test an integrated sensing module
Compare the proposed interface and acquisition architecture with the conventional reference to quantify benefits, limitations and failure conditions.
- 04LONGER-TERMGate: clinical and regulatory pathway
Define a focused medical product
Define one intended use with clinical input and establish the corresponding performance, quality, risk, usability and regulatory development requirements.
04 / CURRENT EVIDENCE
Evidence and its limits.
Architecture proposals, synthetic examples and physical measurements provide different levels of evidence. Their status and limitations are stated separately.
Architecture & protocols
Research specifications, literature mapping, experimental planning and contribution guidance.
Explore the repository ↗Synthetic analysis examples
Synthetic acoustic data and analysis examples support software review. Successful checks do not establish physical or clinical performance.
Run the example ↗Physical & clinical results
The integrated matrix, measured tissue properties, clinical accuracy and treatment outcomes remain to be validated.
Read the research status ↗05 / BUILT ON ENGINEERING EXPERIENCEMedical-device experience.
Medical-device experience.
A systems perspective.
Sadhu Shobab Bollipo
Founder & independent researcher · Bengaluru, India
Connect with Sadhu ↗Experience in medical-device software, laboratory automation and hardware–software integration informs the focus on system integration, measurement traceability and testable requirements.
Sadhu worked at Siemens Healthineers from June 2008 to July 2025. Endorys is an independent initiative: it is not a Siemens Healthineers product, endorsed programme or affiliated venture.
Systems thinkingTraceable engineeringEvidence before claims
Current development concentrates on a defined acoustic experiment. Its results will inform subsequent architecture decisions and application priorities.
Is an Endorys device available for clinical use?
No. Endorys is a pre-prototype research programme. Platform and application illustrations describe proposed configurations. Clinical accuracy, therapeutic benefit and an available medical device have not been established.
Which tissues and applications are in scope?
The programme began with breast tissue assessment and expanded into tissue measurement and a separate materials-testing workstream. The immediate experiment uses a non-biological phantom and does not involve human testing.
Who can contribute to the research?
Acoustic measurement researchers, sensing engineers and clinicians who can contribute to a defined measurement question or intended use. Laboratory access and collaboration arrangements require separate agreement.
What does selective openness mean?
Selected protocols, documentation and reproducibility tools are public under explicit component licences. Future commercial engineering is reviewed separately before release. Existing public licence grants remain in force.
Read our openness policy ↗What are the terms for reusing public material?
Check the applicable file-specific licence. Covered original software uses Apache-2.0 and covered documentation uses CC BY 4.0. Hardware, visual assets and third-party material are excluded unless separately licensed; public availability alone does not grant unrestricted reuse.
Read research licence scope ↗Website source, text, branding and images have separate permissions. See the website rights notice.
06 / START A CONVERSATIONContribute to
Contribute to
the validation programme.
Clinical collaborators
Define a specific clinical decision, its current workflow and the evidence required to justify an additional tissue measurement.
Ultrasound & sensing engineers
Review coupling, geometry and acquisition requirements, and define a rigorous comparison with conventional acoustic measurements.
An initial discussion should identify the measurement question, key assumptions, required evidence and a feasible experimental contribution.